Research Groups

RESEARCH UNIT: Smart Molecular Inorganic and Hybrid Materials

Inorganic Materials and Catalysis Laboratory

Our research has demonstrated that boron clusters are in many cases complementary to organic compounds in biomedical, in materials or energy areas of research. The extraordinarily stability and new properties of these new materials along with the fact that they are not particularly expensive, foresee their applicability in many fields.

The research core of the Inorganic Materials and Catalysis Laboratory (LMI) scientific activity is in the chemistry and applications of boron clusters. Their geometry and their composition based on Boron, a semi-metal, bestow them unique properties largely unexplored. Regarding synthesis, the chemistry of boron clusters has achieved a sufficient degree of maturity that has led to new boron structures. Current efforts aim at developing new protocols to get targeted derivatives in a region-selective way.

Members

  • Prof. Francesc Teixidor - Research Professor
  • Prof. Clara Viñas Teixidor - Research Professor
  • Dr. Rosario Núñez Aguilera - Research Scientist
  • Dr. José Giner Planas - Tenured Scientist
  • Jordi Cortés - Laboratory Technician
  • Dr. Zsolt Kelemen - Postdoctoral Marie Curie Researcher
  • Dr. Albert Ferrer Ugalde - Postdoctoral Researcher
  • Dr. Amirali Yazdi - Postdoctoral Researcher
  • Ana Begoña Buades - PhD Researcher
  • Isabel Guerrero Troyano - PhD Researcher
  • Jewel Ann Maria Xavier - PhD Researcher
  • Joan Soldevila - PhD Researcher
  • Lei Gan - PhD Researcher
  • Miquel Nuez I Martínez - PhD Researcher
  • Sohini Sinha - PhD Researcher
  • Zhen Li - PhD Researcher

Fluorescence morphology dependence of CdSe Quantum NMs. The morphology is dependent on the carboranylthiol used. Each carboranylthiol forces a morphology that determines the fluorescence. Schematic representation of the “in vitro” (with glioblastoma cells) and “in vivo” boron containing drug studies.

Achievements

The group’s attention has been addressed to research in biomedicine, in materials and energy. All of this research has in common the use of boron clusters, boranes, carboranes or metallacarboranes as key components to find new properties or improve old ones. It was proven that the ratio of thiophene to doping agents in PEDOT polymers can be altered by the cation utilized, thus altering their electrical properties. It was found that with only a single metal, single molecule magnets SMM can be observed.  That by judicious choice of the borane as decorating agent different morphologies are found in CdSe dots, so nanorods, nanorings, or tetrapods along with QDs can be generated, resulting in different fluorescent wavelengths. A really fast and high throughput synthetic method has been demonstrated to produce the most promising metallacarborane, which open expectations for large applications. Highly crowded carboranes have been made that pave the way for artificial membranes for ions diffusion. Highly selective drugs sensors have been developed thanks to the anchoring capacity of metallacarboranes.

Stabilization of proteins to denaturation has been demonstrated with metallacarboranes without using complex polymers. Rotamer tunable surfactant/non-surfactant behavior has been demonstrated for metallacarboranes that incorporates a new dimension for molecules crossing a membrane.

Regarding biomaterials for medicine, the LMI group has been very active on the development of Boron cluster-containing multi-functional nanomaterials to be used in nanomedicine. The research has been focused in using boron clusters as a platform to integrate multiple functionalities to achieve new scaffolds to be used either as biomaterial or a single material for multimodal therapies speeding up action treatment and diminishing secondary effects, which results in significant clinical benefits. Highly emissive carborane-fluorophores have been developed to apply as fluorescent dyes for bioimaging studies and as theranostics agents.

Publications

Tuning the deposition parameters for optimizing the faradaic and non-faradaic electrochemical performance of nanowire array-shaped ITO electrodes prepared by electron beam evaporation
R. Pruna, M. López, F. Teixidor
Nanoscale, 11, 276-284, 2019

Synthesis and self-assembly of a carborane-containing ABC triblock terpolymer: morphology control on a dual-stimuli responsive system
R. Fernandez-Alvarez, E. Hlavatovičová, K. Rodzeń, A. Strachota, S. Kereïche, P. Matějíček, J. Cabrera-González, R. Núñez and M. Uchman,
Polymer Chemistry, 10, 2774-2780, 2019

3,2,1 and stop! An innovative, straightforward and clean route for the flash synthesis of metallacarboranes
I. Bennour, A. M. Cioran, F. Teixidor, C. Viñas
Green Chemistry, 21, 1925-1928, 2019

Slow-spin relaxation of a low-spin: S = 1/2 Fe III carborane complex
A. B. Buades, V. S. Arderiu, L. Maxwell, M. Amoza, D. Choquesillo-Lazarte, N. Aliaga-Alcalde, C. Viñas, F. Teixidor, E. Ruiz
Chem. Commun., 55, 3825-3828, 2019

Efficient blue light emitting materials based on: M -carborane-anthracene dyads. Structure, photophysics and bioimaging studies
M. Chaari, Z. Kelemen, D. Choquesillo-Lazarte, N. Gaztelumendi, F. Teixidor, C. Viñas, C. Nogués and R. Núñez
Biomaterials Science, 7, 5324-5337, 2019

Carboranylanilinoquinazoline EGFR-inhibitors: Toward lead-to-candidatestage in the drug-development pipeline
M. Couto, C. Alamón, C. Sánchez, B. Dávila, M. Fernández, N. Lecot, P. Cabral, F. Teixidor, C. Viñas and H. Cerecetto
Future Medicinal Chemistry, 11, 2273-2285, 2019

Are the Accompanying Cations of Doping Anions Influential in Conducting Organic Polymers? The Case of the Popular PEDOT
I. Fuentes, M. J. Mostazo-López, Z. Kelemen, V. Compañ, A. Andrio, E. Morallón, D. Cazorla-Amorós, C. Viñas and F. Teixidor
Chemistry – A European Journal, 25, 14308-14319, 2019

Back cover of the issue
A reversible phase transition of 2D coordination layers by B–H···Cu(II) interactions in a coordination polymer
L. Gan, P. G. Fonquernie, M. E. Light, G. Norjmaa, G. Ujaque, D. Choquesillo-Lazarte, J. Fraile, F. Teixidor, C. Viñas and J. G. Planas
Molecules, 24 (17), article number 3204 (18 pages) , 2019

Icosahedral carboranes as scaffolds for congested regioselective polyaryl compounds: The distinct distance tuning of C-C and its antipodal B-B
Z. Kelemen, A. Pepiol, M. Lupu, R. Sillanpää, M. M. Hänninen, F. Teixidor and C. Viñas
Chemical Communications 55, 8927-8930, 2019

Back cover of the issue
Combining magnetic nanoparticles and icosahedral boron clusters in biocompatible inorganic nanohybrids for cancer therapy
E. Oleshkevich, A. Morancho, A. Saha, K. M. O. Galenkamp, A. Grayston, S. G. Crich, D. Alberti, N. Protti, J. X. Comella, F. Teixidor, A. Rosell and C. Viñas
Nanomedicine-Nanotechnology Biology and Medicine, 20, 101986 (10 pages) , 2019

The Next Stage in Colloidal Synthesis of Aqueous CdSe Quantum Dots: High Throughput and Intense Emissive Properties
A. Saha, A. Saini, C. Vinas and F. Teixidor
ChemNanoMat, 5, 940-947, 2019

A simple membrane with the electroactive [Sulfapyridine-H]+[Co(C2B9H11)2]- for the easy potentiometric detection of sulfonamides
A. Saini, I. Fuentes, C. Viñas, N. Zine, J. Bausells, A. Errachid and F. Teixidor
Journal of Organometallic Chemistry, 893, 32-38, 2019

The key to controlling the morphologies of quantum nanocrystals: Spherical carborane ligands
A. Saini, A. Saha, C. Viñas and F. Teixidor
Chemical Communications, 55, 9817-9820, 2019

Dual Binding Mode of Metallacarborane Produces a Robust Shield on Proteins
I. Fuentes, J. Pujols, C. Viñas, S. Ventura, F. Teixidor
Chemistry-A European Journal, 25, 12820-12829, 2019

Atomistic Simulations of COSAN: Amphiphiles without a Head-and-Tail Design Display Head and Tail” Surfactant Behavior
D. C. Malaspina, C. Viñas, F. Teixidor, J. Faraudo, 
Angew Chem. Int. Ed. 59, 8, 3088-3029, 2019

Periphery Decorated and Core Initiated Neutral and Polyanionic Borane Large molecules: Forthcoming and Promising Properties for Medicinal Applications
C. Viñas, R. Núñez, I. Bennour, F. Teixidor
Current Medicinal Chemistry, 26, 5036-5076, 2019

BOOKS

Highlighting the Binding Behavior of Icosahedral Boron Clusters into Polymers: Synthons, Polymers Preparation and Relevant Properties.
C. Viñas, R. Núñez, I. Romero, F. Teixidor
Libro: Smart Inorganic Polymers: Synthesis, Properties, and Emerging Applications in Materials and Life Sciences, ISBN 978-3-527-34484-0. Eds. Evamarie Hey-Hawkins and Muriel Hissler. 2019, 41-60
DOI: 10.1002/9783527819140.ch2_2.

 

Awards and Recognitions

  • Zsolt Kelemen, MSCA IF Fellow of the Week
  • Back cover of a volume of issue 55 of Chemical Communications from Royal Society of Chemistry.
  • Back cover of volume 63 of issue 25 of Chemistry A European Journal from Wiley.
  • UAB award of doctoral thesis to Elena Oleskevich for her research on "Carboranylphosphinic acids: A New Class of Purely Inorganic Ligands to Generate Polynuclear Compounds and Multifunctional Nanohybrids Materials for Biomedical Applications”. Supervisor Prof. Clara Viñas.
Coordination
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Web & Graphic Editor
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Webmasters
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