Metallacarboranes like [Co(C2B9H11)2]-, which self-assemble, have the property to strongly interact with amines. Therefore, they should be able to interact with certain aminoacids that are present in proteins. This paper reports on the stable coating of Bovine Serum Albumin (BSA) by the metallacarborane [Co(C2B9H11)2]- through the anchoring with the amino residues and fulfilling the complementary surface by self-assembling. Many of the protein’s properties are preserved even at higher temperatures than denaturalization.
Dual Binding Mode of Metallacarborane Produces a Robust Shield on Proteins
Isabel Fuentes, Jordi Pujols, Clara Viñas, Salvador Ventura, Francesc Teixidor
Chem. Eur. J. 25, 12820-12829, 2019
Figure: Bovine Serum Albumin (BSA)’s volume from Dynamic Light Scattering (DLS) and the representations of Na[COSAN] covering a single BSA core molecule (a) first, (b) second, (c) third and (d) fourth layers.